Until a few years ago, the symptoms associated with MS that we discuss in this chapter were often ignored or underplayed by doctors and neurologists. This was, in part, because MS was considered then to produce mainly – often only – physical symptoms directly (and obviously) related to the damage occurring in the nervous system. Other symptoms seemed – at the time – to be very difficult to relate to nervous system damage in this way, so fatigue, cognitive problems and, to a substantial degree, depression, were often seen as not related to the disease process itself. There has been a very substantial change over the last decade and now much greater professional attention is being paid to people who have these symptoms.