Candida is said to be the most common fungal infection of the CNS. About one half of the patients with Candida CNS infection have a lymphocytic pleocytosis and about one half show a predominance of neutrophilis. Some reports have indicated a surprisingly high rate of CNS involvement in the systemic mycoses (blastomycosis, 3%-10%; histoplasmosis, up to 50%; coccidioidomycosis, up to 50%). These fungi most often produce a lymphocytic pleocytosis, but neutrophils may predominate. Cerebrospinal fluid glucose levels are typically reduced but may be normal.