Several well-known disorders affecting skeletal muscle either are not congenital or do not yet have any conspicuously useful laboratory test. Among these are disorders whose primary defect is located in the central nervous system or peripheral nervous system rather than in skeletal muscle itself. In this group are various neurologic diseases that secondarily result in […]
Creatine kinase (CK) is found in heart muscle, skeletal muscle, and brain. It is elevated at some time in about 90%-93% (literature range, 65%-100%) of patients with acute MI. In acute MI, CK behaves similarly to AST. In addition, elevations have also been reported in myocarditis and also in some patients with tachyarrhythmias (mostly ventricular) […]
Serum aspartate aminotransferase (AST; formerly SGOT) is an enzyme found in several organs and tissues, including liver, heart, skeletal muscle, and RBCs. AST elevation from nonhepatic sources is discussed elsewhere. AST elevation originating from the liver is due to some degree of acute liver cell injury. Following onset of acute hepatocellular damage from any etiology, […]
