Bilirubin is formed from breakdown of hemoglobin molecules by the reticuloendothelial system. Newly formed (unconjugated) bilirubin circulates in blood bound nonpermanently to serum albumin and is carried to the liver, where it is extracted by hepatic parenchymal cells, conjugated first with one and then with a second glucuronide molecule to form bilirubin diglucuronide, and then […]