PTH is secreted in a discontinuous (pulsatile) fashion. There is a diurnal variation, with highest values at 2 A.M. (midnight to 4 A.M.) and lowest at noon (10 A.M. -2 P.M.. The parathyroids synthesize intact PTH, consisting of 84 amino acids in a single chain. Metabolic breakdown of intact PTH occurs both inside and outside […]