Articles on Medical Diseases and Conditions

When CML has the typical picture of a WBC count more than 100,000/mm3 (100 x 109/L) with myelocytic predominance, increased platelets, and basophilia, the diagnosis is reasonably safe. Otherwise, the two conditions that most frequently enter the differential diagnosis are agnogenic myeloid metaplasia and leukemoid reaction. CML tends to have a greater degree of leukocytosis […]

Leukemoid reaction is an abnormally marked granulocytic response to some bone marrow stimulus, most commonly infection. Leukemoid reaction is basically the same process as an ordinary leukocytosis except in the degree of response. The expected peripheral blood WBC count response is even more marked than usual and may reach the 50,000-100,000/mm3 (50-100 x 109/L) range […]

Leukemoid reaction is usually defined as a nonleukemic WBC count more than 50,000/mm3 (50 х 109/L) or a differential count with more than 5% metamyelocytes or earlier cells. It is basically a more severe or pronounced form of ordinary nonneoplastic granulocyte reaction. Some conditions associated with leukemoid reaction are severe bacterial infections, severe toxic states […]