When CML has the typical picture of a WBC count more than 100,000/mm3 (100 x 109/L) with myelocytic predominance, increased platelets, and basophilia, the diagnosis is reasonably safe. Otherwise, the two conditions that most frequently enter the differential diagnosis are agnogenic myeloid metaplasia and leukemoid reaction. CML tends to have a greater degree of leukocytosis […]