There are several indications for leukocyte removal. The most frequent reason is development of an immune reaction to antigens on “foreign” transfused leukocytes that constitutes the great majority of febrile nonhemolytic transfusion reactions and by far the most common overall transfusion reaction, especially in multitransfused patients. Second, removal of leukocytes helps prevent microaggregates (miniclots) of […]