Fibrinogen is a blood fraction that is essential for clotting. It is decreased in two ways, both relatively uncommon: (1) by intravascular deposition of fibrin in the form of small clots (DIC) and (2) by inactivation in the presence of primary fibrinolysin. Fibrinogen concentrates used to be prepared commercially but are no longer available due […]
In this section the various coagulation pathway factors are discussed individually, with emphasis on abnormalities for which laboratory tests are useful. Factor I (fibrinogen) Fibrinogen is a glycoprotein that is synthesized in the liver, the liver being a major source of many coagulation factors. Conversion of fibrinogen to fibrin under the influence of thrombin is […]
