There are five major groups of inherited defects in bilirubin metabolism: Gilbert’s syndrome, Crigler-Najjar syndrome (type I), Arias syndrome (Crigler-Najjar syndrome type II), Dubin-Johnson syndrome, and Rotor syndrome. Gilbert’s syndrome. Gilbert’s syndrome is a congenital partial defect in unconjugated bilirubin clearance due to decreased function of the enzyme bilirubin uridine diphosphate-glucuronate glucuronyl transferase (UDP-GT). Males […]