Articles on Medical Diseases and Conditions

When CML has the typical picture of a WBC count more than 100,000/mm3 (100 x 109/L) with myelocytic predominance, increased platelets, and basophilia, the diagnosis is reasonably safe. Otherwise, the two conditions that most frequently enter the differential diagnosis are agnogenic myeloid metaplasia and leukemoid reaction. CML tends to have a greater degree of leukocytosis […]

A disease that is often very difficult to separate from CML is agnogenic (idiopathic) myeloid metaplasia (AMM). It is most common in persons aged 50-60 years. The syndrome results from bone marrow failure and subsequent extramedullary hematopoiesis on a large scale in the spleen and sometimes in the liver and lymph nodes. Actually, the extramedullary […]